The following media release is distributed by UPEI Communications for the Beatrice Hunter癌症研究所.

哈利法克斯NS——多亏了来自 Beatrice Hunter癌症研究所 (BHCRI)， UPEI研究生将从事乳腺癌的研究. 

奥利维尔·菲利普斯博士的硕士学生. 伊利诺伊大学伊利诺伊大学生物系的Patrick 墨菲说, 是UPEI第一个获得29美元研究生奖学金的学生吗,通过BHCRI的癌症研究培训计划(CRTP)获得750美元.  

This CRTP award will provide Philips with a stipend for the next year and a half while he completes his master’s degree. His funded project is “Targeting physiologically available serine biosynthesis pathway metabolites in triple negative breast cancers.”

Breast cancer is the most common and second deadliest cancer in Canadian women. Cancer cells, including breast cancer cells, exhibit changes in metabolism compared to normal cells. Philips’ research will examine metabolism in breast cancer cells that results in production of unusual compounds that may, 反过来, 提供了一种干扰癌症生长和扩散的新方法.   

“Triple negative breast cancer is challenging to treat and has few treatment options,” says Dr. Judy Bray，加拿大癌症协会(CCS)研究副总裁. 在J.D. 欧文,有限的, CCS has awarded an Atlantic Canada 研究 Grant to enable Dr. 墨菲的团队, 包括奥利维尔·飞利浦, to explore a promising new therapy with potential to improve outcomes for people with triple negative breast cancer.” 

墨菲, 飞利浦的主管是谁, 他以前是CRTP培训生吗, having received stipend support while a postdoctoral fellow at Dalhousie University.

“我自己也是一名CRTP实习生, I can attest to how valuable the BHCRI support is in the development of young scientists—in both skill development and networking with researchers in the region,墨菲说.

“I look forward to the training that the CRTP has to offer and the opportunity to work within the talented network of trainees in Atlantic Canada. J的慷慨.D. 欧文,有限的 has inspired me to help others and give back to the community. I hope one day I will be able to help students achieve their goals just as you have helped me,飞利浦说. 

Beatrice Hunter癌症研究所, 通过他们的癌症研究培训项目, provides trainees with access to a program designed to expose them to all aspects of cancer research. Philips is one of three UPEI students who joined the training program in September 2021. 

Philips’ studentship is provided by funds from the Canadian Cancer Society’s J.D. 欧文，有限卓越癌症研究基金. J.D. 欧文,有限的--Excellence in Cancer 研究 Fund is proud to support the Cancer 研究 Training Program at BHCRI.

“The past year has shown us that supporting each other is what matters most. We’ve come together to look after one another—and do what it takes to keep our friends, 邻居, 亲人安全. This donation is about supporting cancer research that is the key to helping our loved ones live longer, fuller生活,吉姆·欧文说, J联合首席执行官.D. 欧文,有限的.

奥利维尔·飞利浦的职业概述:

Breast cancer is the most common and second deadliest cancer in Canadian women. Some breast cancers depend on a protein called PHGDH in order to grow, or metastasize. 大多数旨在阻断这种蛋白质的药物都失败了. Finding new targets for cancers that depend on PHGDH would enhance breast cancer treatment. Several metabolites produced by PHGDH were recently discovered in the 墨菲 Laboratory that are also found in human blood. 这种存在是否能预防PHGDH阻滞剂目前尚不清楚.

This project will focus on whether blood-based metabolites help cancer cells escape PHGDH blockers. 来弄清楚这是怎么发生的, I will block PHGDH in breast cancer cells in media where the metabolites are present or absent. I will then do an experiment called metabolomics to see what metabolites the cells produced in each condition. I will then grow the same cells with metabolites that differ across conditions. In these experiments, I will then look to see how the metabolites affect PHGDH blockers. Finding these metabolites may eventually allow us to discover new proteins that can be blocked in cancers that need PHGDH to grow. 最后, the project will lead to improved understanding of breast cancer metabolism and could provide new breast cancer treatments.

关于加拿大癌症协会的J.D. 欧文，癌症研究有限卓越基金:

2021年，J.D. 欧文有限公司捐了2美元.5 million to the Canadian Cancer Society to establish the Excellence in Cancer 研究 Fund, affirming the company’s longstanding commitment to invest in research in Atlantic Canada. 基金将会建立, 加强, 并扩大该地区癌症研究的潜力和能力, 它将确保最高的质量, most promising ideas and people are supported (based on a rigorous peer review process). This enables scientists to develop and continue their critical research in Atlantic Canada and contribute to the larger national cancer research landscape.

关于Beatrice Hunter癌症研究所:

Created in 2009 through a bequest to the Dalhousie Medical 研究 Foundation, the Beatrice Hunter癌症研究所 exists to foster a collaborative, 富有成效的, 以及大西洋加拿大地区的癌症研究能力建设. Beatrice Hunter癌症研究所 brings together a diverse community of cancer researchers in pursuit of a common goal: to save lives and ease the burden of cancer on individuals, 家庭, 和社会. Beatrice Hunter癌症研究所 provides a meeting place for researchers to share ideas and forge new collaborations and offers a key entry point for students seeking training and careers in cancer research. 联系人:Carla Ross，执行董事(input@bhcri.ca)